• Login
    View Item 
    •   Home
    • Research, Student
    • BEAR Day
    • BEAR Day 2021
    • View Item
    •   Home
    • Research, Student
    • BEAR Day
    • BEAR Day 2021
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MercerCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    About URSA

    Collecting PolicyLicense AgreementDigitization SpecificationsRemoval PolicyHarmful Language Statement

    Statistics

    Display statistics

    Small Drug Molecules that Resemble Bacterial Signaling Molecules Act as Competitive Inhibitors with Intramolecular Communication Signals at Bacterial Receptor Sites

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    TALKKaimari.pdf
    Size:
    13.76Mb
    Format:
    PDF
    Download
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Author
    Kaimari, Abdulraheem
    Malik, Samad
    Patel, Prachi
    
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10898/12669
    Title
    Small Drug Molecules that Resemble Bacterial Signaling Molecules Act as Competitive Inhibitors with Intramolecular Communication Signals at Bacterial Receptor Sites
    Abstract
    Contemporary studies have discovered that bacteria are multilingual, having both intraspecies and interspecies communication capabilities. Through quorum sensing, bacteria quantify their density and unanimously agree on carrying out a certain response (Bassler 2009). Biofilms are virulence factors that form once a bacterial quorum is reached within the host, preventing the host�s immune system from detecting and ultimately eradicating these pathogenic bacteria (Hensel 2020). This study tests certain drugs that could potentially prevent successful bacterial communication, as biofilms impact various industries including medicine, dentistry, and agriculture for years (Urry et al. 2017). The Crystal Violet assays reveal that Glu-8, Gly-8, Gly-30, and Sar-6 drugs had 84.84, 71.48, 62.48, and 58.23 average percent inhibitions in B. subtilis respectively. Glu-8 had 37.20 average percent biofilm inhibition in S. mutans, while Glu-8 in S. aureus was a major biofilm accelerator in the second trial (-31.63%) and inhibitor in the first (29.33%). None of the drugs demonstrated biofilm inhibition in the Congo Red assays. Similarly, none of the tested drugs demonstrated any bacteriostatic effects when added to their bacterial cultures in the Disk Diffusion plates. Likewise, none of the drugs in the Use-Dilution plates were bactericidal. Although Glu-8 in B. subtilis and S. mutans and Sar-6 in B. subtilis were consistent biofilm inhibitors, further Crystal Violet trials are necessary to determine their biofilm inhibition ranges, and to determine whether Glu-8 is an inhibitor or accelerator in S. aureus. Accordingly, the combination of Glycine (Gly) and o-Bromobenzoic acid (bromine attached to the benzene functional group) resulted in an effective biofilm inhibitor without any bacteriostatic or bactericidal effects. Therefore, Glu-69 and Gly-69 should be tested in the future to analyze the effect of two bromines on a benzene ring. By doing so, certain functional groups could be characterized by their success in mimicking bacterial signals and ultimately inhibiting intraspecies communication. The aim is also to test Gly-10 to confirm that bromine attached to a benzene ring in the drug is what causes successful mimicking of endogenous intraspecific ligands, and not the bromine alone.
    Collections
    BEAR Day 2021

    entitlement

     

    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.