• Login
    View Item 
    •   Home
    • Research, Student
    • BEAR Day
    • BEAR Day 2021
    • View Item
    •   Home
    • Research, Student
    • BEAR Day
    • BEAR Day 2021
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MercerCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    About URSA

    Collecting PolicyLicense AgreementDigitization SpecificationsRemoval PolicyHarmful Language Statement

    Statistics

    Display statistics

    The Effect Of Patch Compartment Neuronal Inhibition upon C-Fos Expression In Methamphetamine Addiction

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    POSTMuchandi32.pdf
    Size:
    896.0Kb
    Format:
    PDF
    Download
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Author
    Muchandi, Bhuvaneshwari
    
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10898/12657
    Title
    The Effect Of Patch Compartment Neuronal Inhibition upon C-Fos Expression In Methamphetamine Addiction
    Abstract
    By assessing the nature of cFos neuronal expression in stereotypic habits associated with drug use, treatment models for methamphetamine addiction can be developed to address behavioral issues. The study focuses on the function of the striatum, which is involved in processing environmental information from the cortex to signal the appropriate behavior. Specifically, the patch compartment of the striatum is heavily implicated in addictive patterns through its high levels of mu opioid receptors and possesses an imbalance in cFos neuronal expression compared to its matrix counterpart. Addictive patterns develop through stimulus-response associations to create habit formation with inflexible behaviors, which occur automatically without cognitive processing. The study predicts that selective inhibition of the patch compartment will result in diminished habit formation and stereotypic behaviors associated with methamphetamine abuse. First, the iDREADD vector was inserted through the adeno-associated virus vector into the prelimbic cortex (PLC) and tagged with mCherry to observe the reduction in patch compartment neuronal activity. Then the animals underwent self administration with methamphetamine under a continuous and variable reinforcement schedule to promote habit formation. Aversion training took place in conditioned-place preference chambers to evaluate the inflexible nature of habit formation. Lastly, the rats were sacrificed and immunohistochemistry staining was subsequently performed to analyze cFos neuronal expression. The results indicated a decreased rate of stereotypic behavior within iDREADD infused rats when exposed to noxious stimuli, illustrating the decreased rate of habit formation. Through diminished habit formation, animals can adopt more flexible behavioral patterns to diminish the addictive potential of methamphetamine administration, which can be applied to human models in future research. Future experimentation should be conducted to evaluate the efficacy of inhibiting PLC in equalizing the patch-matrix compartment imbalance.
    Collections
    BEAR Day 2021

    entitlement

     

    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.