• Login
    View Item 
    •   Home
    • Research, Student
    • Atlanta Research Conference
    • Atlanta Research Conference 2021
    • View Item
    •   Home
    • Research, Student
    • Atlanta Research Conference
    • Atlanta Research Conference 2021
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MercerCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    About URSA

    Collecting PolicyLicense AgreementDigitization SpecificationsRemoval PolicyHarmful Language Statement

    Statistics

    Display statistics

    Topical and Transdermal Iontophoretic Delivery of Methotrexate in Healthy and Psoriatic Human Skin

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    ARC21_PHAR_015.pdf
    Size:
    585.7Kb
    Format:
    PDF
    Download
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Author
    Vora, Deepal
    Somayaji, Mahadevabharath R.
    German, Carrie
    Banga, Ajay K.
    Keyword
    College of Pharmacy
    ARC21--Night 1
    
    Metadata
    Show full item record
    URI
    http://hdl.handle.net/10898/12595
    Title
    Topical and Transdermal Iontophoretic Delivery of Methotrexate in Healthy and Psoriatic Human Skin
    Abstract
    Psoriasis is a condition of the skin which involves scales, dry patches, and inflammation. Methotrexate (logP: -0.236, MW: 454.44 g/mol) is administered orally or intravenously to treat psoriasis. The first pass metabolism and systemic side effects associated can be avoided by transdermal delivery. We investigated the iontophoretic delivery of methotrexate using healthy and psoriatic human skin to understand the effect of skin�s disease condition on topical and transdermal delivery. In vitro permeation testing using vertical Franz diffusion cell were conducted. Cathodal iontophoresis (0.5 mA/sq.cm for 4 h) delivered a significantly higher total amount of methotrexate into the skin and receptor when compared to that delivered by passive diffusion and anodal iontophoresis. A current density of 0.2 mA/sq.cm using cathodal iontophoresis and 10mg/mL donor concentration was optimized to obtain the target delivery through healthy human skin. There was no significant difference in receptor delivery for psoriatic skin as compared to healthy skin, while significantly higher methotrexate delivery in skin was observed for psoriatic skin as compared to healthy skin. Thus, cathodal iontophoresis delivered a significantly higher total amount of methotrexate as compared to passive diffusion and anodal iontophoresis. Significantly higher delivery in skin and hence significantly higher total delivery was observed for psoriatic skin as compared to healthy skin.
    Collections
    Atlanta Research Conference 2021

    entitlement

     

    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.