• Management of Crohn's Disease: Early and Aggressive Treatment Using Biologics and Immunomodulators

      Martin, Erin; Sadowski, Catherine (2021)
      Crohn's Disease (CD) is an incurable type of inflammatory bowel disease (IBD), in which the intestines are chronically inflamed, causing intestinal and extra-intestinal symptoms. CD patients experience a cycle of remission and relapse of symptoms as the disease progresses to serious complications, including small bowel obstructions, malnutrition, and decreased quality of life. Since CD is incurable, medical management is the mainstay of treatment to obtain and maintain remission. Traditional treatment relies on anti-inflammatories. New management strategies focuses on early and aggressive therapy with immunomodulators and biologics to reduce the rate of mucosal and intestinal damage early in the disease course.
    • Subcutaneous CGRP Antagonist Injections: A Novel Approach to the Treatment of Chronic Migraines

      Burrows, Caroline; Sadowski, Catherine (2021)
      Nearly 4 million Americans suffer from chronic migraines. These patients have severe headaches that occur for 15 or more days a month, leading to a diminished quality of life. Current recommended therapy is not conducive to all patients, as one study shows 68% of these patients experience at least one medication treatment failure. Within the last few years, the FDA has approved new medications, known as CGRP antagonists, that are proving to be efficacious in the treatment of chronic migraine.