Exploring 5-HT2 Receptors as Targets for Treating Epilepsy in Fragile X Syndrome: A Preclinical Study of Fmr1 Knock-out Mice
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Date
2020
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Exploring 5-HT2 Receptors as Targets for Treating Epilepsy in Fragile X Syndrome: A Preclinical Study of Fmr1 Knock-out MiceAbstract
This project explores the anticonvulsant potential of lorcaserin in Fragile X Syndrome in which epilepsy prevalence is ~25%. We did a full dose response (1-10 mg/kg) in an audiogenic seizure assay in Fmr1 knock-out mice. Lorcaserin did not affect prevalence at any dose but attenuated seizure severity to some extent.Collections