Sex Differences in an Fmr1 Knock-out Mouse Model of Fragile X Syndrome
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Date
2020
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Sex Differences in an Fmr1 Knock-out Mouse Model of Fragile X SyndromeAbstract
Possessing a single X-chromosome, fragile X syndrome (FXS) occurs more frequently in males than females, and FXS males typically have more severe clinical symptoms than FXS females. Genetic mosaicism (X-inactivation) in females with FXS is the presumed, exclusive reason for the lower symptom severity; we explored the hypothesis that other factors - sex hormones or sexually dimorphic brain systems - could be involved.Collections