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    Sex Differences in an Fmr1 Knock-out Mouse Model of Fragile X Syndrome

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    Author
    Jessica Armstrong
    Yiming Chen
    Tanishka Saraf
    Clinton Canal
    Keyword
    Atlanta Research Conference 2020
    College of Pharmacy
    Date
    2020
    
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    URI
    https://hdl.handle.net/10898/12380
    Title
    Sex Differences in an Fmr1 Knock-out Mouse Model of Fragile X Syndrome
    Abstract
    Possessing a single X-chromosome, fragile X syndrome (FXS) occurs more frequently in males than females, and FXS males typically have more severe clinical symptoms than FXS females. Genetic mosaicism (X-inactivation) in females with FXS is the presumed, exclusive reason for the lower symptom severity; we explored the hypothesis that other factors - sex hormones or sexually dimorphic brain systems - could be involved.
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